Research has shown that there are four main causes of fibromyalgia syndrome:

genetic predisposition

hypothalmic-pituitary-adrenal axis dysregulation

pain processing systems

behavioral and psychological factors


The limbic system  (of the brain) is a high-order functional regulator that affects fatigue, pain, sleep, weight, appetite, libido, respiration, temperature, blood pressure, immune and endocrine systems and the modulation of the peripheral system.

The limbic system is the primary mediator of the stress response.

The hypercortisol state of prolonged stress damages neurons.

It is well accepted that victims of child abuse are more likely to develop functional changes in neurons.

Environmental Stressors

For all biologic stressors and environment characterized by the following will amplify the adverse physiologic effects:

lack of control


lack of support

Other Stressors that trigger FMS

catastrophic events

EBV infection


Lyme disease

physical trauma

psychological or emotional stress or trauma


Mariposa Dreams

Plymouth Integrative Medicine Center
Fibromyalgia Doctor ~ Irene Metro MD
44670 Ann Arbor Rd, Ste 100, Plymouth, MI 48170

Call 734.432.1900 for an appointment with Fibromyalgia Doctor ~ Irene C. Metro MD

The information contained on this web site is not intended to treat, diagnose, cure or prevent any disease, nor is it intended to replace proper medical care. All material provided in this web site is provided for educational purposes only. Always seek the advice of your physician or other qualified health care provider with any questions you have regarding a medical condition, and before undertaking any diet, exercise or other health program.

Fibromyalgia doctor Irene C. Metro, MD, Board Certified Internal Medicine, Board Certified American Board of Integrative & Holistic Medicine, is the medical director of the Plymouth Integrative Medicine Center in Livonia, Michigan. This medical clinic has internal medicine, integrative medicine, physical therapy, acupuncture, lifestyle coaching, nutritional counseling, and psychotherapy, and specializes in fibromyalgia, chronic fatigue syndrome, hypertension, high blood pressure, insomnia, anxiety, depression, chronic pain, trigger point therapy, vitamin therapy, and pain relief. This medical clinic is located across from St. Mary Mercy Hospital and is easily accessible from Plymouth, Livonia, Canton, Northville, Redford, Westland, Farmington Hills, Southfield, Dearborn Heights, and other locations in Oakland County and Wayne County Michigan. Call 734-432-1900 to make an appointment with the fibromyalgia doctor MI today!