Research has shown that there are four main causes of fibromyalgia syndrome:

genetic predisposition

hypothalmic-pituitary-adrenal axis dysregulation

pain processing systems

behavioral and psychological factors


Central Nervous System

In the fibromyalgia syndrome (FMS) patient the central nervous system processes pain differently than in the non-FMS patient.

Central Sensitization: The nervous system interprets light stimuli as painful.

Neural hormones affect sleep, pain, immunity, emotions, constriction and dilation of blood vessels.

Abnormal levels of neural hormones (neurotransmitters) in FMS:


Substance P





neuropeptide Y

Autonomic Nervous System Dysfunction

Symptoms can include:

neurally medicated hypotension (NMH)



night / day sweats

nasal congestion



Mariposa Dreams

Plymouth Integrative Medicine Center
Fibromyalgia Doctor ~ Irene Metro MD
44670 Ann Arbor Rd, Ste 100, Plymouth, MI 48170

Call 734.432.1900 for an appointment with Fibromyalgia Doctor ~ Irene C. Metro MD

The information contained on this web site is not intended to treat, diagnose, cure or prevent any disease, nor is it intended to replace proper medical care. All material provided in this web site is provided for educational purposes only. Always seek the advice of your physician or other qualified health care provider with any questions you have regarding a medical condition, and before undertaking any diet, exercise or other health program.

Fibromyalgia doctor Irene C. Metro, MD, Board Certified Internal Medicine, Board Certified American Board of Integrative & Holistic Medicine, is the medical director of the Plymouth Integrative Medicine Center in Livonia, Michigan. This medical clinic has internal medicine, integrative medicine, physical therapy, acupuncture, lifestyle coaching, nutritional counseling, and psychotherapy, and specializes in fibromyalgia, chronic fatigue syndrome, hypertension, high blood pressure, insomnia, anxiety, depression, chronic pain, trigger point therapy, vitamin therapy, and pain relief. This medical clinic is located across from St. Mary Mercy Hospital and is easily accessible from Plymouth, Livonia, Canton, Northville, Redford, Westland, Farmington Hills, Southfield, Dearborn Heights, and other locations in Oakland County and Wayne County Michigan. Call 734-432-1900 to make an appointment with the fibromyalgia doctor MI today!